The war against cancer: Suicide gene therapy
نویسندگان
چکیده
منابع مشابه
Suicide Gene Therapy against Cancer
A major limitation of conventional chemotherapies used in cancer treatments today are low therapeutic indices and side effects that result from drug effects on normal tissues (off target). One of the most innovative approaches to developing antineoplastic agents with increased tumor selectivity is the use of suicide gene therapy. Suicide gene therapy involves delivering a gene product in proxim...
متن کاملThe War Against Vitamin Therapy
I have been involved in megavitamin controversies from 1955 when with two colleagues we [1] published our paper showing that niacin lowered total cholesterol levels. This was quickly confirmed because Dr. W. B. Parsons, Jr[2] . It was easy to measure cholesterol levels. Dr Parsons is one of the most knowledgeable and experienced internists in the use of niacin to lower cholesterol levels. But a...
متن کاملSuicide Gene Therapy for Cancer - Current Strategies.
Current cancer treatments may create profound iatrogenic outcomes. The adverse effects of these treatments still remain, as the serious problems that practicing physicians have to cope with in clinical practice. Although, non-specific cytotoxic agents constitute an effective treatment modality against cancer cells, they also tend to kill normal, quickly dividing cells. On the other hand, therap...
متن کاملAn Enterovirus-Like RNA Construct for Colon Cancer Suicide Gene Therapy
Background: In gene therapy, the use of RNA molecules as therapeutic agents has shown advantages over plasmid DNA, including higher levels of safety. However, transient nature of RNA has been a major obstacle in application of RNA in gene therapy. Methods: Here, we used the internal ribosomal entry site of encephalomyocarditis virus and the 3’ non-translated region of Poliovirus to design an en...
متن کاملEnhancement of HSV-TK/GCV suicide gene therapy of cancer
Gene therapy has become a promising alternative treatment form for cancer. Among the broad range of different genetic means to reduce the tumor growth, herpes simplex virus thymidine kinase/ganciclovir (HSV-TK/GCV) suicide gene therapy regimen is the best known approach. In this type of therapy, cancer cells are manipulated to express HSV-TK, followed by administration of the prodrug, the antiv...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Advances in Modern Oncology Research
سال: 2016
ISSN: 2424-7855,2424-7847
DOI: 10.18282/amor.v2.i3.103